Microneedling with Exosomes: why it is the most advanced regenerative treatment available today
There is a question we often receive, especially with the arrival of the warm season: "Can microneedling with exosomes also be done in spring? Isn't it just a winter treatment?"
The answer, clear and unambiguous, is yes. Microneedling with ASCE Plus SRLV exosomes is a treatment that can be performed all year round — and in this article, we explain exactly why, how it works, and what makes it one of the most advanced protocols available today in regenerative aesthetic medicine.
What exosomes are and why they are so important for the skin
To understand the value of this treatment, we must start with cell biology. Exosomes are extracellular nanovesicles — nanometer-sized structures naturally produced by cells — that act as true biological messengers. They carry proteins, messenger RNA, microRNA, and biochemical signals from one cell to another, instructing tissues on how to regenerate, repair, and renew themselves.
In aesthetic medicine, interest in exosomes arises from a fundamental discovery: when applied to the skin in a targeted way — especially in combination with microneedling, which facilitates their deep absorption — they can activate skin fibroblasts, increase collagen and elastin production, reduce inflammation, and significantly and measurably even out skin tone.
These are not marketing promises. These are scientifically documented mechanisms of action, supported by clinical data.
Not all exosomes are the same: the three main types
It is important to clarify an aspect that often causes confusion: there are different types of exosomes, each formulated for a specific goal and a different body area.
1. Exosomes for facial skin
This is the most well-known and used type in facial aesthetic medicine. It acts on skin regeneration, collagen production, skin tone, and firmness. It is the category to which ASCE Plus SRLV belongs, the protocol we use at Yanabeauté.
2. Exosomes for the scalp and hair
Specifically formulated to counter hair loss and improve scalp quality. They have a different active ingredient profile, designed to stimulate hair follicles and prolong the hair growth phase.
3. Exosomes for intimate areas
An emerging category in the field of gynecological aesthetic medicine, indicated for rejuvenation of intimate tissues, hydration, and improvement of mucosal trophism.
Understanding this distinction is essential to choose the correct treatment based on the therapeutic goal. In the context of this article, we will focus on the first type: exosomes for facial skin and their use in combination with microneedling.
ASCE Plus SRLV: the technology behind the protocol
The product we use for our microneedling protocol with exosomes is ASCE Plus SRLV by ExoCoBio — and it was not chosen by chance.
ASCE Plus SRLV is the world’s first professional solution containing plant-derived exosomes, sourced from the stem cells of the Damask Rose (Rosa damascena). The underlying technology is ExoSCRT™ (Exosome-based Stem Cell-free Rejuvenation Therapy), protected by two international patents (KR 10-1895916 and KR 10-2058444), developed by ExoCoBio in South Korea — one of the world’s centers of excellence for exosome research.
Why plant-derived exosomes?
It might seem counterintuitive: why use exosomes derived from a plant — the Damask rose — to treat human skin? The answer lies in a surprising discovery: the exosomes from the stem cells of this specific rose have shape, size, and biological behavior remarkably similar to those of human stem cell exosomes.
In particular, most of the microRNAs contained in these plant exosomes are de novo sequences — many of which correspond to human sequences already known to be involved in cell proliferation and anti-inflammatory processes. This means that, once applied to the skin, they can effectively communicate with human cells, activating measurable biological responses.
In addition, the plant origin guarantees an excellent safety profile: no risk of transmission of animal or human pathogens, high tolerability, and documented biocompatibility.
The formulation: 5 billion purified exosomes
Each vial of ASCE Plus SRLV contains 5 billion purified exosomes (20 mg + 5 ml) in lyophilized powder form, to be reconstituted at the time of treatment. The ExoSCRT™ technology ensures a highly selective isolation and purification process: only pure exosomes are extracted, representing 0.1-0.5% of the starting conditioned media. This guarantees a concentration and quality of active ingredients unattainable with less refined extraction methods.
Documented benefits: the numbers that make the difference
Clinical data published by ExoCoBio are clear. Treatment with ASCE Plus SRLV, combined with microneedling, produces measurable results on multiple fronts:
Collagen: increase up to 690%
Collagen is the main structural protein of the skin. Its production progressively decreases with age — it is estimated that after age 25, the skin loses about 1% of collagen each year. ASCE Plus SRLV can stimulate skin fibroblasts to produce up to 690% more collagen compared to baseline levels. The visible result is firmer, plumper skin with a significant reduction in fine wrinkles and sagging.
Elastin: increase up to 300%
Elastin is the protein responsible for skin elasticity — the skin’s ability to return to its original shape after being stretched or compressed. As we age, elastin fibers degrade and are no longer efficiently replaced. Treatment with ASCE Plus SRLV stimulates elastin production by up to 300% more, restoring the skin’s firmness and "bounce" that are lost over time.
Melanin: reduction up to 75%
One of the most appreciated effects of the treatment is its evening and depigmenting action. Damask rose exosomes act on the melanin production mechanisms, reducing it by up to 75%. This results in a visible lightening of sun spots, post-inflammatory pigmentation (PIH), and hyperpigmentation in general, with a brightness and evenness that is hard to achieve with other single treatments.
Reversal of aging processes
Through the key factors PRDXs (peroxiredoxins, powerful cellular antioxidants), Let-7b (an anti-inflammatory microRNA), and CD44 (a receptor that significantly increases the absorption capacity of active ingredients), ASCE Plus SRLV acts on the deep cellular mechanisms of skin aging, not just its surface effects.
Restoration of the skin barrier
The skin barrier — the outermost layer of the skin, responsible for retaining hydration and protecting against external aggressors — is strengthened and normalized. Cell turnover is regulated, producing healthier, more resilient, and deeply hydrated skin.
Powerful anti-inflammatory and antioxidant action
The treatment has a marked anti-inflammatory effect, making it suitable even for sensitive, reactive, or redness-prone skin. The antioxidant action protects cells from oxidative stress — one of the main accelerators of skin aging — by counteracting damage from free radicals.
How the protocol works: microneedling + exosomes
Microneedling — also known as micro-needle therapy or collagen induction therapy — is a well-established technique that uses a device with micro-needles to create thousands of microchannels in the skin. This process itself stimulates collagen production through the skin’s natural repair response, but the real breakthrough happens when combined with exosomes.
The microchannels created during microneedling act as preferential entry points: exosomes, normally too large to penetrate the intact skin barrier, are delivered directly into the deeper layers of the skin, where they can exert their regenerative action massively and effectively.
The protocol we perform at Yanabeauté includes:
- Skin preparation with thorough cleansing and disinfection
- Application of topical anesthetic to ensure maximum comfort during the treatment
- Microneedling session with depth and intensity customized based on skin type and therapeutic goal
- Immediate application of the reconstituted ASCE Plus SRLV solution, which is absorbed through the newly created microchannels
- Recovery phase and post-care with personalized instructions
The treatment lasts on average 60-75 minutes. Downtime is minimal: in most cases, there is a temporary redness that resolves within 24-48 hours, allowing a quick return to normal activities.
Why do it also in spring (and all year round)
One of the most common misconceptions concerns the seasonality of microneedling. Many people believe it is a treatment to be done exclusively in autumn-winter to avoid sun exposure. In reality, with the proper precautions — especially the diligent use of high-factor sun protection — microneedling with exosomes is safe and highly effective at any time of the year.
Spring, in particular, is a strategic time for this treatment for several reasons:
Recovery from winter. The cold months, artificial heating, temperature fluctuations, and lower environmental hydration stress the skin barrier. Spring is the ideal time to restore it and regenerate the skin before summer.
Sun preparation. Strengthening the skin barrier and optimizing collagen production before the first sun exposures means arriving at summer with skin that is more resilient, elastic, and less vulnerable to UV damage.
Action on winter spots. The depigmenting action of the exosomes is especially useful in spring to even out discolorations accumulated during the winter months.
Minimal recovery time. The low downtime of the treatment perfectly suits an active lifestyle, without requiring isolation periods or excessive restrictions.
The recommended cycle generally includes 3-4 sessions spaced monthly, followed by maintenance sessions. Results appear progressively and consolidate in the weeks following each treatment, as the skin produces new collagen fibers and the regenerative mechanisms activated by the exosomes take effect.
Who is microneedling with ASCE Plus SRLV exosomes for
This treatment is suitable for a wide range of people and skin conditions. In particular, it is recommended for those who want to:
- Counteract signs of aging — fine wrinkles, loss of firmness, tissue sagging
- Improve texture — enlarged pores, uneven skin, or superficial acne scars
- Even out skin tone — sun spots, hyperpigmentation, discolorations
- Regenerate the skin after a period of stress — seasonal changes, diet, maternity, periods of fatigue
- Maintain healthy and radiant skin as a preventive and maintenance protocol
- Address the first signs of aging preventively, starting from age 30
There are no particular age-related contraindications: the protocol is adjustable and always personalized after a thorough consultation with our team.
Yanabeauté Milan: your reference for regenerative aesthetic medicine in Brera
At Yanabeauté, in the heart of the Brera district in Milan, microneedling with ASCE Plus SRLV exosomes is performed by specialized professionals, with personalized protocols for every skin type and aesthetic goal.
Every treatment begins with a thorough consultation to analyze your skin's characteristics, understand your expectations, and define the most suitable path. There is no one-size-fits-all protocol: personalization is the heart of our approach.
If you have questions, doubts, or want to understand if this treatment is right for you, our team is available to answer any curiosity.
Discover the treatment and book your consultation →
Yanabeauté S.r.l.s. · Via Mercato 5, 20121 Milan (Brera) · yanabeaute.it
Aesthetic Beauty Awards 2025 – Best Advanced Aesthetic Protocol in Europe