Microneedling is today one of the most requested skin regeneration treatments worldwide, but not all microneedling is the same. The difference — the real one, the one you see in the mirror — is not made by the needle alone: it’s made by what is delivered into the skin at the exact moment it is most receptive.
It is from this awareness that the Exclusive Yanabeauté Microneedling was born, the tailored protocol of our advanced aesthetic institute in the heart of Brera, Milan. Not a one-size-fits-all treatment, but three distinct versions — Biologique Recherche Serums, PDRN, and Exosomes — selected with you after a careful skin analysis, to precisely meet your face’s specific needs: deep nourishment, cellular repair, or advanced anti-aging.
In this article, we explain how microneedling works, what distinguishes the three versions of our exclusive protocol, who each is suitable for, and what to expect before, during, and after the treatment.
What microneedling is and why it really works
Microneedling (or collagen induction therapy) is an advanced aesthetic technique that uses ultra-fine sterile micro-needles to create controlled micro-perforations in the epidermis and superficial dermis.
These micro-lesions, completely invisible to the naked eye, trigger two extraordinarily effective mechanisms:
- The skin’s natural regenerative response. The micro-stimulus activates fibroblasts, the cells responsible for producing collagen and elastin. The result, over the following weeks, is progressively firmer, toned, and smoother skin.
- The opening of micro-delivery channels. For a few minutes, the skin barrier becomes temporarily permeable: it is the ideal window to deeply penetrate active ingredients that, when normally applied on the surface, would never pass the stratum corneum. The absorption capacity of the actives can increase exponentially compared to a simple topical application.
And this is exactly where the difference lies between generic microneedling and Exclusive Yanabeauté Microneedling: choosing the right active ingredient, for the right skin, at the right time.
Why "Exclusive": the Yanabeauté method
At Yanabeauté, we don’t believe in standardized treatments. Every skin has a story, a biological age, a hydration level, a regenerative capacity, and different goals. That’s why our microneedling protocol always begins, first and foremost, with a professional skin consultation and analysis.
Only after understanding the real needs of your face do we guide you in choosing among the three treatment versions:
- Version 1 – Biologique Recherche Serums: deep regeneration and nourishment
- Version 2 – PDRN (polynucleotides): cellular repair and intense hydration
- Version 3 – Exosomes: advanced anti-aging and next-generation regeneration
Let’s look at them in detail.
Version 1 – Microneedling with Biologique Recherche Serums: deep regeneration and nourishment
Biologique Recherche is one of the most prestigious and rigorous cosmetic maisons in the world, renowned for its pure, highly concentrated, fragrance-free formulations built around the concept of Skin Instant: the real condition of the skin at a precise moment in its life.
Yanabeauté works exclusively with Biologique Recherche, and in Exclusive Microneedling this partnership becomes a real advantage: the authentic serums from the maison — selected during the session based on your skin analysis — are delivered deeply through the micro-channels created by the treatment, multiplying their effectiveness.
Who this version is for
- Dull, tired, devitalized skin that has lost its radiance
- Dehydrated or malnourished skin, affected by stress, seasons, travel, or hormonal changes
- For those seeking a first approach to microneedling with a gentle but visibly effective protocol
- For those who want a glow treatment ahead of an important event
The results
From the very first sessions, the skin appears more radiant, plumped, and even. After a treatment cycle, the skin texture refines and the complexion regains that "healthy skin" quality that no makeup can replicate.
Version 2 – Microneedling with PDRN: cellular repair and intense hydration
PDRN (Polydeoxyribonucleotide, polynucleotides) is one of the most studied active ingredients in regenerative aesthetic medicine in recent years. These are purified DNA fragments with very high biocompatibility, known for their ability to:
- Stimulate tissue regeneration by activating receptors that accelerate cellular repair processes
- Promote collagen synthesis and fibroblast proliferation
- Improve deep hydration, retaining water in the dermis and redensifying the skin
- Reduce micro-scars, post-acne marks, and texture irregularities
Delivered through microneedling, PDRN reaches exactly the skin level where it expresses its maximum regenerative potential.
Who this version is for
- Skin with uneven texture, enlarged pores, small scars, or post-acne marks
- Fragilized or thinned skin that needs redensification
- Those suffering from deep dehydration and loss of tone
- Those seeking a repairing treatment after periods of intense skin stress (sun, harsh winter, aggressive treatments)
The results
PDRN works "from within": in the weeks following the treatment cycle, the skin appears visibly denser, more elastic, hydrated, and even. It is the ideal protocol for those who want to repair before rejuvenating.
Version 3 – Microneedling with Exosomes: the latest advanced anti-aging
Exosomes are currently the most advanced frontier in skin regeneration, so much so that they are called the true revolution of regenerative skincare. They are extracellular nanovesicles that act as "biological messengers": they carry growth factors, proteins, and cellular information that instruct skin cells to regenerate.
At Yanabeauté, we use protocols based on latest generation exosomes at very high concentration, delivered through microneedling to maximize absorption and biological activity.
Exosomes act on multiple fronts simultaneously:
- Accelerates cell turnover and skin repair processes
- Intensely stimulates collagen and elastin, counteracting wrinkles and sagging
- Reduces inflammation and improves redness and discoloration
- Globally revitalizes skin quality: tone, firmness, radiance, texture
Who this version is for
- Mature skin that desires an intensive anti-aging action without resorting to invasive treatments
- Who has wrinkles, loss of tone, and sagging in the early stages or already visible
- For those seeking the maximum regenerative result available today in advanced aesthetics
- For those who want to prolong and enhance the results of other treatments in the Yanabeauté program
The results
Microneedling with exosomes produces a global and progressive improvement: the skin appears younger, smoother, and "regenerated" session after session, with results that continue to evolve in the following weeks thanks to deep biological stimulation.
How the treatment is performed at Yanabeauté
Each Exclusive Microneedling session follows a strict protocol:
- Consultation and skin analysis — we assess skin condition, goals, and treatment history together, and define the most suitable version (Biologique Recherche, PDRN, or Exosomes).
- Deep cleansing and preparation — the skin is cleansed and prepared according to our institute’s professional method.
- Microneedling treatment — performed with professional devices and sterile single-use needles, with calibrated depth zone by zone.
- Active ingredient delivery — the selected serum is applied during and after the procedure, at the moment of maximum skin receptivity.
- Soothing and protective phase — we close the session with calming products and personalized post-treatment instructions.
The session lasts on average 60 minutes and is generally well tolerated: only a slight sensation of warmth or tingling is felt.
Post-treatment: what to expect
In the 24–48 hours following treatment, mild redness similar to a slight sunburn is normal and resolves spontaneously. In the following days, we recommend:
- Avoid direct sun exposure and always apply a high SPF protection
- Temporarily discontinue exfoliants, retinoids, and aggressive actives
- Moisturize the skin with the products recommended by our team
- Avoid sauna, swimming pool, and intense sports activities for 48 hours
The first results are noticeable after just a few days; the full regenerative effect develops over the next 4–6 weeks, when collagen neosynthesis reaches its peak.
How many sessions are needed?
It depends on the chosen version and the initial condition of the skin. In general:
- For a revitalizing and glow effect, 1–2 sessions may be enough
- For repair and redensification (PDRN) goals, a cycle of 3–4 sessions spaced 3–4 weeks apart is recommended
- For an intensive anti-aging path with exosomes, the ideal protocol includes 3 sessions, with possible maintenance touch-ups.
During the consultation, we define the optimal path together, which can also include other excellent treatments from our institute, such as HydraFacial, Dermalux LED Therapy, or the Yanabeauté Exclusive Facial, always respecting the correct timing between treatments.
Microneedling in Milan: why choose Yanabeauté
Among Milan’s beauty centers, Yanabeauté stands out for an approach that combines advanced aesthetics, excellent products, and absolute personalization:
- Three exclusive protocols, not a one-size-fits-all treatment
- Partnerships with elite brands like Biologique Recherche
- Cutting-edge actives (high concentration PDRN and exosomes)
- Professional skin analysis before every treatment
- A wellness boutique in the heart of Brera, at Via Mercato 5
Frequently asked questions about Exclusive Microneedling
Is microneedling painful?
No. The sensation is a slight tingling or warmth. The needle depth is always calibrated based on sensitivity and the treated area.
Can I wear makeup after the treatment?
We recommend waiting at least 24 hours to let the skin breathe and maximize the absorption of active ingredients.
What is the best time to do it?
Microneedling can be done all year round, with the precaution of avoiding direct sun exposure in the following days and always using high sun protection.
How do I choose between Biologique Recherche, PDRN, and exosomes?
You don’t have to choose alone: that’s our job. During the consultation, we analyze your skin and recommend the most effective version for your goals.
Is microneedling suitable for sensitive skin?
Yes, with tailored protocols. The version with Biologique Recherche serums, in particular, is ideal as a gentle and nourishing approach.
Book your Exclusive Microneedling in Milan Brera
Your skin deserves a treatment designed exclusively for it. Discover which of the three versions of Yanabeauté Exclusive Microneedling is right for you: book your personalized consultation.
📍 Yanabeauté – Via Mercato 5, Milan (Brera)
📞 Tel. 345 2708211
💻 www.yanabeaute.it
Book now & transform your skin.