Microneedling PDRN Booster:
deep regeneration
that your skin was waiting for

Three synergistic actives, a precision technique, and 60 minutes of professional care. The new Yanabeauté Microneedling PDRN Booster takes skin regeneration to an unprecedented level — visible from the very first session.

If you have ever looked at your photos from a few years ago and thought "my skin had a different glow" — it’s not nostalgia. It’s physiology speaking. Over time, collagen production slows down, cellular hydration decreases, and the first signs of aging appear in the skin’s texture. The good news is that advanced aesthetic science now has tools capable of reversing, or at least significantly slowing down, this process. One of these is the Microneedling PDRN Booster.

At Yanabeauté, our premium clinic in the heart of the Brera district in Milan, we have introduced this next-generation regenerative protocol, the result of the synergy between a highly effective delivery technique — professional microneedling — and one of the most advanced serums on the market: Préime PDRN Booster by Préime DermaCeuticals.

In this article, we explain everything you need to know: what PDRN and microneedling are, why they work so well together, what results you can expect, and who this treatment is suitable for.

What is PDRN and why it is revolutionizing professional skin care

PDRN (Polydeoxyribonucleotide) is a biologically derived molecule obtained from purified salmon DNA — a species particularly studied for the extraordinary similarity of its DNA to human DNA. This molecular affinity is the key to its effectiveness: PDRN is naturally recognized and "welcomed" by skin tissues, without risk of rejection.

The mechanism of action of PDRN is based on the activation of specific receptors called adenosine A2A receptors. This activation triggers a cascade of beneficial biological processes: it stimulates the activity of fibroblasts — the cells responsible for producing collagen and elastin — promotes neovascularization (the formation of new blood vessels), and accelerates the natural tissue repair processes.

The result? Skin that is not simply "nourished" on the surface but literally regenerated from within. This is why PDRN is now at the center of research in aesthetic dermatology and is increasingly used in advanced aesthetic medicine protocols worldwide.

"PDRN does not mask the signs of aging — it corrects them at the root, stimulating the skin to produce on its own what it needs."

The Préime PDRN Booster we use at Yanabeauté combines polynucleotide with two other synergistic actives: Hyaluronic Acid and Glutathione. Three components that work on different fronts and enhance each other for a complete regenerating, hydrating, and brightening effect.

The three main active ingredients of the PDRN Booster

Microneedling: the gateway to the deep dermis

Microneedling is an aesthetic medicine technique based on creating micro-channels in the skin using precision needles. The logic is elegant in its simplicity: intact skin is designed to act as a barrier — that is exactly its job. But this same barrier also prevents topical actives from penetrating beyond the surface layer.

With professional microneedling, the micro-channels created allow for deep transcutaneous delivery of the serum applied during the treatment. This is not an abrasion: the needles work with controlled precision at millimetric depths, simultaneously activating the skin's natural healing response (which further stimulates collagen production) and creating access pathways for the active ingredients of the PDRN Booster.

The result of combining microneedling + PDRN is radically superior to the topical application of the same active ingredients: the concentration of active ingredients reaching the dermis is incomparably higher, along with the treatment's effectiveness.

Why choose professional microneedling

There are self-treatment devices, but there is a substantial difference compared to a treatment performed by a qualified professional. Needle depth, penetration speed, process sterility, and the selection of the correct serum for the skin type are variables that require specific training and expertise. At Yanabeauté, the treatment is performed with state-of-the-art devices, in a certified clinical environment, following protocols validated by scientific literature.

What the Microneedling PDRN Booster does: concrete benefits

The benefits of the treatment are not theoretical — they are measurable and visible. Here is what you can expect, session after session.

Deep skin regeneration

PDRN stimulates the metabolic activity of fibroblasts, promoting the synthesis of new collagen and elastin. The skin regains thickness, density, and firmness. The first sessions show a progressive effect that consolidates in the following weeks as the newly formed collagen matures.

Intense and lasting hydration

Hyaluronic Acid delivered deeply acts as an internal water reserve. Unlike moisturizing creams, which act only on the stratum corneum, dermal hydration guarantees a visible and lasting plumping effect: the skin appears fuller, smoother, and more radiant already within 48 hours after treatment.

Evening of tone and radiance

Glutathione works on two fronts: it neutralizes free radicals that accelerate aging and inhibits melanogenesis (excessive melanin production), reducing spots and evening out skin tone. The result is that "from within" radiance that is the hallmark of healthy skin.

Reduction of fine wrinkles and improvement of texture

With the proliferation of collagen and the deep filling guaranteed by Hyaluronic Acid, superficial wrinkles visibly soften. The skin texture — enlarged pores, irregularities, roughness — improves session after session, restoring a smooth and even appearance.

Who the Microneedling PDRN Booster is for

The treatment is suitable for a very wide range of people. In particular, we recommend it for those who have:

• Early or advanced signs of skin aging (fine wrinkles, loss of firmness)
• Dull complexion, lacking brightness or with sun damage spots
• Deeply dehydrated skin with a persistent feeling of dryness
• Irregular texture, enlarged pores, or superficial acne scars
• Desire for prevention and maintenance of skin quality over time
• Skin recovering post-summer or from environmental stress

The treatment adapts to all skin phototypes. Before each session, our professional performs a personalized skin assessment to define the optimal treatment parameters — needle depth, number of passes, and concentration of active ingredients — ensuring tailored results for your specific needs.

When it’s better to wait

There are some temporary contraindications: pregnancy and breastfeeding, presence of active skin infections in the treatment area, use of anticoagulant or immunosuppressive drugs, or acute inflammatory dermatological conditions such as rosacea in its acute phase. In any case, during the preliminary consultation, we collect a complete medical history to ensure the treatment is safe and appropriate.

How the session is conducted at Yanabeauté

Each Microneedling PDRN Booster session is designed to be not only effective but also a wellness experience. Here’s what happens during the 60 minutes of your appointment.

1. Cleansing and skin preparation

The session begins with a professional cleansing to remove all traces of makeup, sebum, and impurities. The skin must be completely clean to ensure treatment hygiene and maximize the absorption of active ingredients.

2. Application of topical anesthetic (if necessary)

For more sensitive skin, we apply a topical anesthetic cream with a setting time of about 20 minutes, making the procedure practically painless. Tolerance to microneedling varies from person to person: many clients describe it as a slight tingling, completely manageable.

3. Microneedling with PDRN Booster delivery

The heart of the treatment: the professional device works on the face with precise movements, while the Préime PDRN serum is continuously applied during the process. The micro-channels created ensure that the active ingredients are absorbed deeply in real time.

4. Soothing mask and post-treatment care

At the end of microneedling, we apply a soothing and hydrating mask to calm any redness and maximize hydration benefits. The session concludes with the application of a high SPF sunscreen — a crucial step in the days following treatment.

Post-treatment: what to expect and how to care for your skin

In the first 24–48 hours after treatment, mild redness similar to a light sunburn is normal. This is a completely normal physiological response, indicating that the regeneration mechanisms have been activated. The redness usually disappears within 24 hours in most cases.

For the following days, we recommend:

• Apply SPF 50+ sunscreen daily (essential).
• Moisturize generously with soothing products free of acids or retinoids for at least 5 days.
• Avoid direct sun exposure and intense heat sources (sauna, steam bath) for 48–72 hours.
• Do not use makeup in the first 12–24 hours.
• Reintroduce retinol and exfoliating acids only after 5–7 days, as advised by the professional.

The skin will gradually become more radiant and smooth over the next 7–14 days as the regeneration processes consolidate.

Frequently asked questions about the Microneedling PDRN Booster

Why choose Yanabeauté for your PDRN treatment in Milan

Yanabeauté is not a beauty farm: it is a specialized aesthetic clinic, born from a passion for excellence and the belief that every skin deserves a tailored approach. In the heart of Brera, Milan, we offer an experience that combines scientific rigor, cutting-edge technologies, and attention to detail that you feel from the moment you step through the door at Via Mercato 5.

Our team is trained on protocols validated by international scientific research. The products we use — including the Préime PDRN Booster by EMA Aesthetics — are selected based on safety, effectiveness, and innovation criteria. We do not offer standardized treatments, but personalized paths that always start with an in-depth analysis of your skin and your goals.

Yanabeauté was awarded at the Aesthetic Beauty Awards 2025 as the best clinic for Advanced Aesthetic Protocol in Europe — a recognition that reflects the daily commitment we put into every single session.

"Skin care is an act of respect towards yourself. We are here to guide you on this journey, with expertise and heart."